Tricyclic antidepressant toxicity.
نویسنده
چکیده
Tricyclic antidepressants are dibenzazepine derivatives with adrenergic, anticholinergic, and direct cardio-depressant activity. Double-blind clinical studies show TCAD to be efficacious for two-thirds of depressed patients. Cardiac toxicity is significant, especially on diseased myocardium. Serious arrhythmias and intracardiac blocks have been reported on therapeutic doses. Tricyclic antidepressant overdose is a serious condition which is becoming progressively more common. The agents' principal toxicities are to the nervous system and the heart. The syndrome can be divided into three stages of varying severity. The vast majority of cases are in the mild Stage I. Some patients reach Stage II with major CNS effects and increasing intracardiac block. Stage III, which encompassed less than 5% of poisonings, is a potentially fatal situation with respiratory arrest, convulsions, and ventricular arrhythmias. Prevention is extremely important in poisoning therapy. Supportive measures are all that is generally needed for mild poisoning. Moderate and severe overdoses will require respiratory support, anticonvulsants, physostigmine, and beta-blockers. Cardioversion and pacing may be necessary.
منابع مشابه
Comparative evaluation of Wide QRS Interval and R Changes in Avr Lead in Predicting Severe Complications of Tricyclic Antidepressant Poisoning
Background: Tricyclic antidepressants (TCAS) Poisoning is the most common poisoning in the Poisoning Emergency Department of Noor Hospital, Isfahan, Iran. The objective of this study was to compare QRS interval duration with RaVR³3mm and R/SaVR³ 0.7 in predicting: serious complications of acute TCA toxicity. Methods and Materials: This study was descriptive – analytic and prospective cohort....
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Significant toxicity in a young female after low-dose tricyclic antidepressant ingestion.
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متن کاملTricyclic antidepressant overdose: a review.
Overdoses of tricyclic antidepressants are among the commonest causes of drug poisoning seen in accident and emergency departments. This review discusses the pharmacokinetics, clinical presentation and treatment of tricyclic overdose.
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ورودعنوان ژورنال:
- Clinical toxicology
دوره 11 4 شماره
صفحات -
تاریخ انتشار 1977